| Gene |
NR1H2
|
| Protein Name |
NR1H2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor NER) (Nuclear receptor subfamily 1 group H member 2) (Ubiquitously-expressed nuclear receptor) |
| Protein Family |
Nuclear hormone receptor family |
| NCBI Gene ID |
7376
|
| UniProt ID |
P55055
|
| Enzyme Class |
- |
| Molecular Weight |
50974 |
| Protein Length |
460 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). |
| Gene Ontology |
GO:0000122; GO:0000976; GO:0000977; GO:0000978; GO:0000981; GO:0001077; GO:0003677; GO:0003707; GO:0004879; GO:0005634; GO:0005654; GO:0005737; GO:0006367; GO:0006629; GO:0007275; GO:0008134; GO:0008270; GO:0010745; GO:0010867; GO:0010875; GO:0010884; GO:0010887; GO:0030154; GO:0030374; GO:0032270; GO:0032369; GO:0032376; GO:0034191; GO:0038023; GO:0042632; GO:0044255; GO:0045723; GO:0045861; GO:0045892; GO:0045893; GO:0045944; GO:0046965; GO:0048384; GO:0048550; GO:0051006; GO:0051117; GO:0055088; GO:0060336; GO:0071222; GO:0090108; GO:0090187; GO:0090340; GO:0090575; GO:0120163 |
