| Gene |
CASP6
|
| Protein Name |
CASP6_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11] |
| Protein Family |
Peptidase C14A family |
| NCBI Gene ID |
839
|
| UniProt ID |
P55212
|
| Enzyme Class |
3.4.22.59 |
| Molecular Weight |
33310 |
| Protein Length |
293 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-. |
| Localization |
Cytoplasm. |
| Function (UniProt annotation) |
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. |
| Gene Ontology |
GO:0004197; GO:0005654; GO:0005737; GO:0005829; GO:0006508; GO:0006915; GO:0008234; GO:0030855; GO:0042802; GO:0042981; GO:0072734; GO:0097153; GO:0097194; GO:0097200 |
