CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	HDAC4
Protein Name	HDAC4_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Protein Family	Histone deacetylase family
NCBI Gene ID	9759
UniProt ID	P56524
Enzyme Class	3.5.1.98
Molecular Weight	119040
Protein Length	1084
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Localization	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.
Function (UniProt annotation)	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).
Gene Ontology	GO:0000118; GO:0000122; GO:0000978; GO:0001085; GO:0001501; GO:0002076; GO:0003714; GO:0004407; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006338; GO:0006476; GO:0006954; GO:0007399; GO:0008134; GO:0008270; GO:0008284; GO:0008285; GO:0010592; GO:0010832; GO:0010882; GO:0014894; GO:0014898; GO:0014911; GO:0016575; GO:0017053; GO:0019789; GO:0019901; GO:0030018; GO:0030183; GO:0030955; GO:0031594; GO:0031672; GO:0032041; GO:0033235; GO:0033558; GO:0033613; GO:0034983; GO:0040029; GO:0042113; GO:0042493; GO:0042641; GO:0042802; GO:0042826; GO:0043393; GO:0043433; GO:0043525; GO:0045668; GO:0045820; GO:0045892; GO:0045893; GO:0045944; GO:0048661; GO:0048742; GO:0051091; GO:0070491; GO:0070555; GO:0070932; GO:0070933; GO:0071260; GO:0071356; GO:0071374; GO:1902894; GO:1903428; GO:1990841

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2D (Q13557)	Homo sapiens	S210	YGKTQHSSLDQSSPP	0.529	0.7036	TP	certain	experimental	72 \| 73 \| 8 \|	17179159	-	In vitro and in vivo
MARK2 (Q7KZI7)	Homo sapiens	S246	FPLRKTASEPNLKLR	0.871	0.6269	TP	certain	experimental	148 \| 55 \| 73 \| 3 \| 72 \|	16980613	-	In vivo
SIK3 (M5FMX3)	Homo sapiens	S246	FPLRKTASEPNLKLR	0.871	0.6269	TP	certain	experimental	72 \| 73 \| 74 \| 55 \|	23393134	-	-
SIK2 (Q9H0K1)	Homo sapiens	S246	FPLRKTASEPNLKLR	0.871	0.6269	TP	certain	experimental	72 \| 73 \| 74 \| 55 \|	23393134	-	-
CAMK4 (Q16566)	Homo sapiens	S467	RPLGRTQSAPLPQNA	0.904	0.8655	-	-	-	-	11470791	Non high throughput (11470791)	-
CAMK4 (Q16566)	Homo sapiens	S632	RPLSRAQSSPASATF	0.945	0.7369	-	-	-	-	11470791	Non high throughput (11470791)	-
SIK1 (P57059)	Homo sapiens	S246	FPLRKTASEPNLKLR	0.871	0.6269	-	-	-	-	-	-	-
SIK1 (P57059)	Homo sapiens	S467	RPLGRTQSAPLPQNA	0.904	0.8655	-	-	-	-	-	-	-
CAMK2D (Q13557)	Homo sapiens	S632	RPLSRAQSSPASATF	0.945	0.7369	-	-	-	-	-	-	-
CAMK4 (Q16566)	Homo sapiens	S246	FPLRKTASEPNLKLR	0.871	0.6269	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

NCI Nature PID Pathways

Pathway ID	Pathway Name
hdac_classi_pathway	Signaling events mediated by HDAC Class I
hdac_classii_pathway	Signaling events mediated by HDAC Class II
hdac_classiii_pathway	Signaling events mediated by HDAC Class III
ranbp2pathway	Sumoylation by RanBP2 regulates transcriptional repression