CaMKipedia | Result

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Sequence Viewer

Gene

SIK2

Synonyms

KIAA0781 QIK SNF1LK2

Protein Name

Serine/threonine-protein kinase SIK2

UniProt ID

Q9H0K1

Ensembl Gene ID

9606.ENSP00000305976

NCBI Gene ID

23235

Molecular Weight

1,03,915

Protein Length

926

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm

Function

Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene Ontology

GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0031588; GO:0032007; GO:0035556; GO:0042149; GO:0046626; GO:0046777

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Crtc2 (Q3U182)	Mus musculus	S171	SALNRTSSDSALHTS	-	0.6661	TP	certain	experimental	23 \| 72 \| 73 \| 8 \|	15454081	-	In vitro and in vivo
HDAC4 (P56524)	Homo sapiens	S246	FPLRKTASEPNLKLR	0.871	0.6269	TP	certain	experimental	72 \| 73 \| 74 \| 55 \|	23393134	-	-
HDAC5 (Q9UQL6)	Homo sapiens	S259	FPLRKTASEPNLKVR	0.835	0.6806	TP	certain	experimental	72 \| 73 \| 74 \| 55 \|	23393134	-	-
VCP (P55072)	Homo sapiens	S770	QQSRGFGSFRFPSGN	0.013	0.6375	TP	certain	experimental	23 \| 72 \| 9 \| 30 \| 3 \| 16 \|	24129571	-	-
CEP250 * (Q9BV73)	Homo sapiens	S2392	AGLHHSLSHSLLAVA	0.829	0.5176	TP	certain	experimental	74 \| 55 \| 72 \| 31 \|	20708153	-	-
AKT1 (P31749)	Homo sapiens	S473	RPHFPQFSYSASGTA	0.952	0.5419	TP	likely	experimental	140 \|	20708153	-	-
Irs1 (P35570)	Rattus norvegicus	S789	QHLRLSSSSGRLRYT	-	0.7289	-	-	-	-	-	-	In vitro
CEP250 (Q9BV73)	Homo sapiens	S2394	LHHSLSHSLLAVAQA	0.827	0.4979	-	-	-	-	-	-	In vitro and in vivo
PIK3R1 (P27986)	Homo sapiens	S154	STLYRTQSSSNLAEL	0.197	0.2884	-	-	-	-	-	-	in-vitro
SIK2 (Q9H0K1)	Homo sapiens	S90	YQVMETKSMLYLVTE	0.001	0.0341	-	-	-	-	-	-	in-vitro
CDK5R1 (Q15078)	Homo sapiens	S91	ENLKKSLSCANLSTF	0.448	0.3704	-	-	-	-	-	-	in-vitro and in-vivo
Crtc3 (Q91X84)	Mus musculus	S329	SGLQSSRSNPSIQAT	-	0.725	-	-	-	-	-	-	in-vitro
Crtc3 (Q91X84)	Mus musculus	S162	SALNRTNSDSALHTS	-	0.6375	-	-	-	-	-	-	in-vitro
Crtc3 (Q91X84)	Mus musculus	S370	SLRLFSLSNPSLSTT	-	0.4979	-	-	-	-	-	-	in-vitro
PIK3R1 (P27986)	Homo sapiens	S541	RISEIIDSRRRLEED	0.765	0.3704	-	-	-	-	-	-	in-vitro and in-vivo
SIK2 (Q9H0K1)	Homo sapiens	S343	RLKSHRSSFPVEQRL	0.658	0.3948	-	-	-	-	-	-	in-vitro
SIK2 (Q9H0K1)	Homo sapiens	S358	DGRQRRPSTIAEQTV	0.953	0.6227	-	-	-	-	-	-	in-vitro
Crtc3 (Q91X84)	Mus musculus	S62	LTQYHGGSLPNVSQL	-	0.6183	-	-	-	-	-	-	in-vitro
IRS1 (P35568)	Homo sapiens	S794	QHLRLSTSSGRLLYA	0.309	0.5951	-	-	-	-	-	-	-
CRTC2 (Q53ET0)	Homo sapiens	S171	SALNRTSSDSALHTS	0.886	0.662	-	-	-	-	-	-	-
CRTC1 (Q6UUV9)	Homo sapiens	S151	TSWRRTNSDSALHQS	0.759	0.7629	-	-	-	-	-	-	-
IRS1 (A0A024R499)	Homo sapiens	S794	QHLRLSTSSGRLLYA	-	0.5951	-	-	-	-	-	-	-
CRTC3 (Q6UUV7)	Homo sapiens	S329	SGLQSSRSNPSIQAT	0.525	0.7505	-	-	-	-	-	-	-
CRTC3 (Q6UUV7)	Homo sapiens	S162	SALNRTNSDSALHTS	0.89	0.6322	-	-	-	-	-	-	-
CRTC3 (Q6UUV7)	Homo sapiens	S370	SLRLFSLSNPSLSTT	0.898	0.5139	-	-	-	-	-	-	-
CRTC3 (Q6UUV7)	Homo sapiens	S62	LTQYHGGSLPNVSQL	0.771	0.5901	-	-	-	-	-	-	-

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found