| Gene |
PLN
|
| Protein Name |
PPLA_CANLF |
| Organism |
Canis lupus familiaris (Dog) (Canis familiaris) |
| Alternative name(s) |
Cardiac phospholamban (PLB) |
| Protein Family |
Phospholamban family |
| NCBI Gene ID |
414755
|
| UniProt ID |
P61012
|
| Enzyme Class |
- |
| Molecular Weight |
6080 |
| Protein Length |
52 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Endoplasmic reticulum membrane |
| Function (UniProt annotation) |
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). |
| Gene Ontology |
GO:0005246; GO:0006816; GO:0006874; GO:0007219; GO:0010459; GO:0010881; GO:0031966; GO:0032780; GO:0033017; GO:0042030; GO:0048738; GO:0051924; GO:0060314; GO:0086004; GO:0086023; GO:0086092; GO:0090534; GO:1901020; GO:1901077; GO:1901877; GO:1901895; GO:1902081 |
