CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Pln
Protein Name	PPLA_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Cardiac phospholamban (PLB)
Protein Family	Phospholamban family
NCBI Gene ID	18821
UniProt ID	P61014
Enzyme Class	-
Molecular Weight	6095
Protein Length	52
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Endoplasmic reticulum membrane
Function (UniProt annotation)	Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
Gene Ontology	GO:0002026; GO:0005246; GO:0006816; GO:0006874; GO:0007219; GO:0008016; GO:0010043; GO:0010459; GO:0010880; GO:0010881; GO:0016529; GO:0031966; GO:0031982; GO:0032868; GO:0032991; GO:0033017; GO:0033574; GO:0042030; GO:0045822; GO:0048738; GO:0051260; GO:0051924; GO:0060314; GO:0086004; GO:0086023; GO:0086092; GO:0090279; GO:0090534; GO:1901077; GO:1901877; GO:1901895

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Camk2d* (P15791)	Rattus norvegicus	T17	SAIRRASTIEMPQQA	N/A	0.1791	TP	likely	experimental	73 \| 55 \| 148 \|	14761894	Non high throughput (N/A)	-
CAMK2D (Q13557)	Homo sapiens	S16	RSAIRRASTIEMPQQ	N/A	0.0909	-	-	-	-	11694533	Non high throughput (11694533)	-
CAMK2A (Q9UQM7)	Homo sapiens	S16	RSAIRRASTIEMPQQ	N/A	0.0909	-	-	-	-	2544595	Non high throughput (2544595)	-
CAMK2A (Q9UQM7)	Homo sapiens	T17	SAIRRASTIEMPQQA	N/A	0.1791	-	-	-	-	10988285, 2544595	Non high throughput (10988285, 2544595)	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
mmu04020	Calcium signaling pathway
mmu05414	Dilated cardiomyopathy

No NCI Nature pathways found