| Gene |
PSME3
|
| Protein Name |
PSME3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma) |
| Protein Family |
PA28 family |
| NCBI Gene ID |
10197
|
| UniProt ID |
P61289
|
| Enzyme Class |
- |
| Molecular Weight |
29506 |
| Protein Length |
254 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). |
| Gene Ontology |
GO:0000502; GO:0002039; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006915; GO:0007049; GO:0008537; GO:0010950; GO:0016020; GO:0016579; GO:0042802; GO:0043687; GO:0061133; GO:0061136; GO:0097371; GO:2000045; GO:2001237 |
