| Gene |
Cdk5r1
|
| Protein Name |
CD5R1_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] |
| Protein Family |
Cyclin-dependent kinase 5 activator family |
| NCBI Gene ID |
116671
|
| UniProt ID |
P61810
|
| Enzyme Class |
- |
| Molecular Weight |
34031 |
| Protein Length |
307 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cyclin-dependent kinase 5 activator 1, p35: Cell membrane |
| Function (UniProt annotation) |
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity). |
| Gene Ontology |
GO:0001764; GO:0002020; GO:0005509; GO:0005634; GO:0005654; GO:0005737; GO:0005886; GO:0007158; GO:0007213; GO:0007411; GO:0007413; GO:0007420; GO:0009792; GO:0014069; GO:0016020; GO:0016301; GO:0016533; GO:0016534; GO:0018107; GO:0019901; GO:0021549; GO:0021722; GO:0021766; GO:0021819; GO:0030182; GO:0030424; GO:0030425; GO:0030426; GO:0030517; GO:0031175; GO:0031594; GO:0032956; GO:0035235; GO:0035255; GO:0042501; GO:0043025; GO:0043197; GO:0043292; GO:0043525; GO:0043539; GO:0045296; GO:0045892; GO:0046875; GO:0048013; GO:0048471; GO:0048511; GO:0048675; GO:0051015; GO:0061001; GO:0070507; GO:0071158; GO:0090314; GO:0098693; GO:0098793 |
