| Gene |
Eif4e
|
| Protein Name |
IF4E_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) |
| Protein Family |
Eukaryotic initiation factor 4E family |
| NCBI Gene ID |
13684
|
| UniProt ID |
P63073
|
| Enzyme Class |
- |
| Molecular Weight |
25053 |
| Protein Length |
217 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, P-body |
| Function (UniProt annotation) |
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
| Gene Ontology |
GO:0000082; GO:0000340; GO:0000932; GO:0001662; GO:0003743; GO:0005737; GO:0005829; GO:0005845; GO:0006417; GO:0010494; GO:0016281; GO:0016442; GO:0017148; GO:0019827; GO:0019899; GO:0030324; GO:0031370; GO:0032991; GO:0033391; GO:0036464; GO:0045182; GO:0045665; GO:0045931; GO:0048471; GO:0070491; GO:0071549; GO:0098794; GO:0098978; GO:0099524; GO:0099578 |
