| Gene |
YBX1
|
| Protein Name |
YBOX1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Nuclease-sensitive element-binding protein 1 (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Y-box transcription factor) (Y-box-binding protein 1) (YB-1) |
| Protein Family |
N/A |
| NCBI Gene ID |
4904
|
| UniProt ID |
P67809
|
| Enzyme Class |
- |
| Molecular Weight |
35924 |
| Protein Length |
324 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Nucleus. Cytoplasmic granule Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress. |
| Function (UniProt annotation) |
Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.; The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. |
| Gene Ontology |
GO:0000398; GO:0000978; GO:0000981; GO:0001077; GO:0003677; GO:0003690; GO:0003697; GO:0003700; GO:0003723; GO:0005576; GO:0005634; GO:0005654; GO:0005689; GO:0005737; GO:0005829; GO:0006355; GO:0006366; GO:0007219; GO:0010494; GO:0031965; GO:0043231; GO:0045944; GO:0051020; GO:0051781; GO:0070062; GO:0070934; GO:0070937; GO:0071204; GO:1903608; GO:1990904 |
