| Gene |
Vasp
|
| Protein Name |
VASP_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Vasodilator-stimulated phosphoprotein (VASP) |
| Protein Family |
Ena/VASP family |
| NCBI Gene ID |
22323
|
| UniProt ID |
P70460
|
| Enzyme Class |
- |
| Molecular Weight |
39667 |
| Protein Length |
375 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity). |
| Gene Ontology |
GO:0001843; GO:0003779; GO:0005522; GO:0005829; GO:0005856; GO:0005886; GO:0005923; GO:0005925; GO:0007411; GO:0008154; GO:0017124; GO:0030027; GO:0030036; GO:0030175; GO:0030838; GO:0031258; GO:0031527; GO:0051289 |
