| Gene |
DLG4
|
| Protein Name |
DLG4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) |
| Protein Family |
MAGUK family |
| NCBI Gene ID |
1742
|
| UniProt ID |
P78352
|
| Enzyme Class |
- |
| Molecular Weight |
80495 |
| Protein Length |
724 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. |
| Gene Ontology |
GO:0000165; GO:0002091; GO:0005088; GO:0005737; GO:0005783; GO:0005829; GO:0005886; GO:0007165; GO:0007204; GO:0007268; GO:0007399; GO:0007612; GO:0008021; GO:0008022; GO:0014069; GO:0015276; GO:0016188; GO:0019900; GO:0019903; GO:0030054; GO:0030165; GO:0030666; GO:0030863; GO:0031234; GO:0031594; GO:0031697; GO:0031748; GO:0031812; GO:0032281; GO:0032839; GO:0033130; GO:0035255; GO:0035418; GO:0035865; GO:0043005; GO:0043113; GO:0043197; GO:0044224; GO:0044306; GO:0044309; GO:0044877; GO:0045184; GO:0045202; GO:0045211; GO:0048169; GO:0050806; GO:0060076; GO:0060997; GO:0061098; GO:0065003; GO:0097109; GO:0097110; GO:0097113; GO:0097120; GO:0098609; GO:0098839; GO:0098970; GO:0150012; GO:2000310; GO:2000463 |
