| Gene |
SMAD3
|
| Protein Name |
SMAD3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) |
| Protein Family |
Dwarfin/SMAD family |
| NCBI Gene ID |
4088
|
| UniProt ID |
P84022
|
| Enzyme Class |
- |
| Molecular Weight |
48081 |
| Protein Length |
425 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Gene Ontology |
GO:0000122; GO:0000790; GO:0000978; GO:0000981; GO:0000983; GO:0000987; GO:0001102; GO:0001228; GO:0001657; GO:0001666; GO:0001701; GO:0001707; GO:0001756; GO:0001889; GO:0001947; GO:0002076; GO:0002520; GO:0003700; GO:0003712; GO:0005160; GO:0005518; GO:0005634; GO:0005637; GO:0005654; GO:0005667; GO:0005737; GO:0005829; GO:0005886; GO:0006357; GO:0006919; GO:0006955; GO:0007050; GO:0007179; GO:0007183; GO:0007492; GO:0008013; GO:0008134; GO:0008270; GO:0009880; GO:0010628; GO:0010694; GO:0010718; GO:0016202; GO:0016579; GO:0017015; GO:0017151; GO:0019049; GO:0019901; GO:0019902; GO:0023019; GO:0030308; GO:0030325; GO:0030335; GO:0030501; GO:0030512; GO:0030618; GO:0030878; GO:0031053; GO:0031490; GO:0031625; GO:0031962; GO:0032332; GO:0032731; GO:0032909; GO:0032916; GO:0032924; GO:0033689; GO:0035259; GO:0035326; GO:0038092; GO:0042060; GO:0042110; GO:0042177; GO:0042307; GO:0042802; GO:0042803; GO:0043066; GO:0043130; GO:0043235; GO:0043425; GO:0043565; GO:0044212; GO:0045216; GO:0045429; GO:0045599; GO:0045668; GO:0045893; GO:0045930; GO:0045944; GO:0046982; GO:0048340; GO:0048589; GO:0048617; GO:0048701; GO:0050678; GO:0050728; GO:0050776; GO:0050821; GO:0050927; GO:0051091; GO:0051098; GO:0051481; GO:0051496; GO:0051894; GO:0060039; GO:0060290; GO:0060395; GO:0061045; GO:0061767; GO:0070306; GO:0070410; GO:0070412; GO:0070878; GO:0071141; GO:0071144; GO:0071345; GO:0071560; GO:0090263; GO:0097191; GO:0097296; GO:1901203; GO:1902895; GO:1903243 |
