| Gene |
CDK16
|
| Protein Name |
CDK16_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
5127
|
| UniProt ID |
Q00536
|
| Enzyme Class |
2.7.11.22 |
| Molecular Weight |
55716 |
| Protein Length |
496 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY. |
| Function (UniProt annotation) |
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). |
| Gene Ontology |
GO:0004674; GO:0004693; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0006468; GO:0006887; GO:0007283; GO:0008021; GO:0015630; GO:0030054; GO:0030252; GO:0031175; GO:0031234; GO:0043005; GO:0061178 |
