CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Il6st
Protein Name	IL6RB_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Protein Family	Type I cytokine receptor family
NCBI Gene ID	16195
UniProt ID	Q00560
Enzyme Class	-
Molecular Weight	102451
Protein Length	917
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:1602143). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:10661409). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (PubMed:10661409, PubMed:26255596, PubMed:25057188, PubMed:8552649). Has a role in embryonic development (PubMed:10661409). Does not bind IL6 (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (PubMed:10377352). Required for expression of TRPA1 in nociceptive neurons (PubMed:25057188). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (PubMed:25228504). Required for normal trabecular bone mass and cortical bone composition (PubMed:24339143, PubMed:9348227, PubMed:26255596).
Gene Ontology	GO:0004896; GO:0004897; GO:0004915; GO:0004923; GO:0004924; GO:0005127; GO:0005138; GO:0005615; GO:0005896; GO:0005900; GO:0005977; GO:0006642; GO:0007165; GO:0008284; GO:0008593; GO:0009897; GO:0014911; GO:0019221; GO:0019838; GO:0019955; GO:0019981; GO:0030425; GO:0032809; GO:0034097; GO:0038154; GO:0038165; GO:0042102; GO:0042531; GO:0043025; GO:0043235; GO:0044297; GO:0045669; GO:0048711; GO:0048861; GO:0051481; GO:0070102; GO:0070104; GO:0070106; GO:0070110; GO:0070120

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S780	QVFSRSESTQPLLDS	N/A	0.6755	-	-	-	-	16036214	Non high throughput (16036214)	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found