| Gene |
Mecp2
|
| Protein Name |
MECP2_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2) |
| Protein Family |
N/A |
| NCBI Gene ID |
29386
|
| UniProt ID |
Q00566
|
| Enzyme Class |
- |
| Molecular Weight |
53047 |
| Protein Length |
492 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). |
| Gene Ontology |
GO:0000122; GO:0000400; GO:0000785; GO:0000790; GO:0000792; GO:0003677; GO:0003682; GO:0005634; GO:0005829; GO:0007507; GO:0008327; GO:0009314; GO:0010212; GO:0010288; GO:0010385; GO:0010628; GO:0010629; GO:0014003; GO:0014070; GO:0019899; GO:0019904; GO:0021510; GO:0021549; GO:0021740; GO:0021756; GO:0021766; GO:0021772; GO:0021794; GO:0021987; GO:0030182; GO:0031490; GO:0031915; GO:0032091; GO:0032355; GO:0032991; GO:0035176; GO:0035865; GO:0042220; GO:0042826; GO:0044030; GO:0045322; GO:0045892; GO:0048286; GO:0048709; GO:0048712; GO:0050807; GO:0060999; GO:0061000; GO:0071317; GO:0098978; GO:1901953; GO:1901956; GO:1903860; GO:1903861; GO:1905492; GO:1990841; GO:2000635 |
