| Gene |
Cacna1b
|
| Protein Name |
CAC1B_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) |
| Protein Family |
Calcium channel alpha-1 subunit (TC 1.A.1.11) family |
| NCBI Gene ID |
N/A
|
| UniProt ID |
Q02294
|
| Enzyme Class |
- |
| Molecular Weight |
262256 |
| Protein Length |
2336 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Membrane; Multi-pass membrane protein. |
| Function (UniProt annotation) |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (PubMed:1317580). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. |
| Gene Ontology |
GO:0001956; GO:0005245; GO:0005509; GO:0005524; GO:0005886; GO:0005891; GO:0006816; GO:0007268; GO:0008331; GO:0014070; GO:0019233; GO:0032991; GO:0033574; GO:0034765; GO:0043005; GO:0043025; GO:0043198; GO:0043679; GO:0045471; GO:0051721; GO:0070509; GO:0098685; GO:0098978; GO:0099635 |
