CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	GLO1
Protein Name	LGUL_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Lactoylglutathione lyase (EC 4.4.1.5) (Aldoketomutase) (Glyoxalase I) (Glx I) (Ketone-aldehyde mutase) (Methylglyoxalase) (S-D-lactoylglutathione methylglyoxal lyase)
Protein Family	Glyoxalase I family
NCBI Gene ID	2739
UniProt ID	Q04760
Enzyme Class	4.4.1.5
Molecular Weight	20778
Protein Length	184
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	CATALYTIC ACTIVITY: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
Localization	N/A
Function (UniProt annotation)	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.
Gene Ontology	GO:0004462; GO:0005634; GO:0005737; GO:0005829; GO:0005886; GO:0005975; GO:0006090; GO:0006357; GO:0006749; GO:0008270; GO:0009438; GO:0030316; GO:0043066; GO:0070062

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	T107	ELTHNWGTEDDETQS	0.487	0.4831	-	-	-	-	-	-	In vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa00620	Pyruvate metabolism

No NCI Nature pathways found