| Gene |
LIPE
|
| Protein Name |
LIPS_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Hormone-sensitive lipase (HSL) (EC 3.1.1.79) |
| Protein Family |
'GDXG' lipolytic enzyme family |
| NCBI Gene ID |
3991
|
| UniProt ID |
Q05469
|
| Enzyme Class |
3.1.1.79 |
| Molecular Weight |
116598 |
| Protein Length |
1076 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate.; Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.; Monoacylglycerol + H(2)O = glycerol + a carboxylate. |
| Localization |
Cell membrane. Membrane, caveola. Cytoplasm, cytosol. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. |
| Function (UniProt annotation) |
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. |
| Gene Ontology |
GO:0004806; GO:0005811; GO:0005829; GO:0005901; GO:0006468; GO:0008203; GO:0016042; GO:0017171; GO:0019433; GO:0019901; GO:0033878; GO:0042758; GO:0046340 |
