CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	CALD1
Protein Name	CALD1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Caldesmon (CDM)
Protein Family	Caldesmon family
NCBI Gene ID	800
UniProt ID	Q05682
Enzyme Class	-
Molecular Weight	93231
Protein Length	793
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm, cytoskeleton
Function (UniProt annotation)	Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Gene Ontology	GO:0003779; GO:0005516; GO:0005523; GO:0005829; GO:0005856; GO:0005886; GO:0006936; GO:0015629; GO:0017022; GO:0030016; GO:0030478; GO:0043231; GO:0045296

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MYLK (Q15746)	Homo sapiens	S700	KPTKPAASDLPVPAE	0.182	0.7951	-	-	-	-	-	-	-
MYLK (Q15746)	Homo sapiens	S73	VEVNAQNSVPDEEAK	0.782	0.8828	-	-	-	-	-	-	-
MYLK (Q15746)	Homo sapiens	S744	GLKVGVSSRINEWLT	0.457	0.5254	-	-	-	-	-	-	-
CAMK2A (Q9UQM7)	Homo sapiens	S73	VEVNAQNSVPDEEAK	0.782	0.8828	-	-	-	-	-	-	-
MYLK (Q15746)	Homo sapiens	T666	KSSGVKSTHQAAIVS	0.107	0.6227	-	-	-	-	-	-	-
MYLK (Q15746)	Homo sapiens	T735	AGTPNKETAGLKVGV	0.259	0.7459	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found