| Gene |
GRM1
|
| Protein Name |
GRM1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Metabotropic glutamate receptor 1 (mGluR1) |
| Protein Family |
G-protein coupled receptor 3 family |
| NCBI Gene ID |
2911
|
| UniProt ID |
Q13255
|
| Enzyme Class |
- |
| Molecular Weight |
132357 |
| Protein Length |
1194 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. |
| Gene Ontology |
GO:0000186; GO:0000187; GO:0004930; GO:0005634; GO:0005886; GO:0005887; GO:0007186; GO:0007216; GO:0007268; GO:0007626; GO:0008066; GO:0019233; GO:0030425; GO:0038037; GO:0038038; GO:0042802; GO:0051482; GO:0051930; GO:0051966; GO:0071257; GO:0098685; GO:0098839; GO:0098872; GO:0098978; GO:0099530; GO:0099583 |
