| Gene |
MAD2L1
|
| Protein Name |
MD2L1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1) |
| Protein Family |
MAD2 family |
| NCBI Gene ID |
4085
|
| UniProt ID |
Q13257
|
| Enzyme Class |
- |
| Molecular Weight |
23510 |
| Protein Length |
205 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. |
| Function (UniProt annotation) |
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. |
| Gene Ontology |
GO:0000070; GO:0000776; GO:0000777; GO:0000922; GO:0005634; GO:0005654; GO:0005694; GO:0005829; GO:0007093; GO:0007094; GO:0008022; GO:0031145; GO:0042177; GO:0042802; GO:0042803; GO:0043066; GO:0044615; GO:0045930; GO:0048471; GO:0051301; GO:0072686; GO:0090267; GO:1904667 |
