| Gene |
TNK1
|
| Protein Name |
TNK1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
8711
|
| UniProt ID |
Q13470
|
| Enzyme Class |
2.7.10.2 |
| Molecular Weight |
72468 |
| Protein Length |
666 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. |
| Gene Ontology |
GO:0004713; GO:0004715; GO:0005524; GO:0005737; GO:0005829; GO:0006468; GO:0016020; GO:0030154; GO:0030308; GO:0038083; GO:0042127; GO:0046580; GO:0046777 |
