Graphics credits: COMPARTMENTS | More Info
Parameter | Value |
---|---|
Gene | RIN1 |
Protein Name | RIN1_HUMAN |
Organism | Homo sapiens (Human) |
Alternative name(s) | Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1) |
Protein Family | RIN (Ras interaction/interference) family |
NCBI Gene ID | 9610 |
UniProt ID | Q13671 |
Enzyme Class | - |
Molecular Weight | 84099 |
Protein Length | 783 |
Protein Domain | InterPro | Pfam |
3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase | SwissModel |
Gene Expression | Gene Expression Atlas |
Function and Disease | OMIM |
Protein-protein Interaction Database | STRING | IntAct | MINT |
Kinase Database | Phospho.ELM | PhosphoSite | NetworKIN |
Catalytic Activity (UniProt annotation) | - |
Localization | Cytoplasm Note=Some amount is membrane-associated. |
Function (UniProt annotation) | Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. |
Gene Ontology | GO:0005096; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0006897; GO:0007165; GO:0007613; GO:0008306; GO:0017112; GO:0030425; GO:0031914; GO:0043025 |
Gene Name | Organism | P-Site | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
---|---|---|---|---|---|---|---|---|---|---|---|---|
PRKD1 (Q15139) | Homo sapiens | S292 | QLLRRESSVGYRVPA | 0.737 | 0.5533 | TP | certain | experimental | 55 | 62 | 73 | 30 | 72 | 148 | 39 | | 21209314 | - |
|
PRKD1 (Q15139) | Homo sapiens | S351 | RPLLRSMSAAFCSLL | 0.732 | 0.3983 | TP | certain | experimental | 72 | 9 | 30 | 55 | | 21209314 | - |
|
PRKD2 (Q9BZL6) | Homo sapiens | S292 | QLLRRESSVGYRVPA | 0.737 | 0.5533 | - | - | - | - | - | - |
|
Reactome Pathways
No KEGG pathways found
No NCI Nature pathways found