CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	CACNA1C
Protein Name	CAC1C_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
Protein Family	Calcium channel alpha-1 subunit (TC 1.A.1.11) family
NCBI Gene ID	775
UniProt ID	Q13936
Enzyme Class	-
Molecular Weight	248977
Protein Length	2221
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Gene Ontology	GO:0002520; GO:0005245; GO:0005516; GO:0005737; GO:0005886; GO:0005887; GO:0005891; GO:0006816; GO:0007204; GO:0007507; GO:0008331; GO:0010881; GO:0014069; GO:0016021; GO:0030018; GO:0030054; GO:0030425; GO:0035115; GO:0035585; GO:0043010; GO:0043204; GO:0045211; GO:0046872; GO:0050796; GO:0051393; GO:0060402; GO:0061337; GO:0061577; GO:0070509; GO:0070588; GO:0086002; GO:0086007; GO:0086012; GO:0086045; GO:0086056; GO:0086064; GO:0086091; GO:0098911; GO:0098912; GO:1990454

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKD1 (Q15139)	Homo sapiens	S1898	LRKANPSRCHSRESQ	N/A	N/A	-	-	-	-	-	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found