| Gene |
CDK13
|
| Protein Name |
CDK13_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
8621
|
| UniProt ID |
Q14004
|
| Enzyme Class |
2.7.11.22; 2.7.11.23 |
| Molecular Weight |
164923 |
| Protein Length |
1512 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. |
| Localization |
Nucleus speckle |
| Function (UniProt annotation) |
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. |
| Gene Ontology |
GO:0000307; GO:0000380; GO:0000790; GO:0002945; GO:0003723; GO:0004672; GO:0004693; GO:0005524; GO:0005576; GO:0005615; GO:0005634; GO:0005654; GO:0005694; GO:0005794; GO:0005829; GO:0006368; GO:0006468; GO:0007088; GO:0007275; GO:0008024; GO:0008134; GO:0008284; GO:0008353; GO:0016032; GO:0016607; GO:0019901; GO:0019908; GO:0030097; GO:0030332; GO:0032968; GO:0043312; GO:0044212; GO:0045944; GO:0070816; GO:1904813; GO:2000737 |
