| Gene |
ARHGEF7
|
| Protein Name |
ARHG7_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) |
| Protein Family |
N/A |
| NCBI Gene ID |
8874
|
| UniProt ID |
Q14155
|
| Enzyme Class |
- |
| Molecular Weight |
90012 |
| Protein Length |
803 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell junction, focal adhesion Note=Detected at cell adhesions. A small proportion is detected at focal adhesions. |
| Function (UniProt annotation) |
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
| Gene Ontology |
GO:0000322; GO:0001726; GO:0002244; GO:0005085; GO:0005089; GO:0005829; GO:0005886; GO:0005925; GO:0005938; GO:0007030; GO:0007165; GO:0007186; GO:0007399; GO:0010763; GO:0019901; GO:0030027; GO:0030032; GO:0032092; GO:0032991; GO:0035023; GO:0035556; GO:0042059; GO:0043005; GO:0043025; GO:0043065; GO:0043547; GO:0048013; GO:0048041; GO:0051056; GO:0060124; GO:1900026; GO:1904424; GO:2000394 |
