| Gene |
TFDP1
|
| Protein Name |
TFDP1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1) |
| Protein Family |
E2F/DP family |
| NCBI Gene ID |
7027
|
| UniProt ID |
Q14186
|
| Enzyme Class |
- |
| Molecular Weight |
45070 |
| Protein Length |
410 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812). |
| Gene Ontology |
GO:0000083; GO:0000981; GO:0003677; GO:0003700; GO:0003713; GO:0005634; GO:0005654; GO:0005739; GO:0005829; GO:0006357; GO:0006977; GO:0008134; GO:0008283; GO:0008544; GO:0019904; GO:0043276; GO:0045944; GO:0070317; GO:0070345; GO:0090575; GO:1900740; GO:2000278 |
