| Gene |
ESPL1
|
| Protein Name |
ESPL1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) |
| Protein Family |
N/A |
| NCBI Gene ID |
9700
|
| UniProt ID |
Q14674
|
| Enzyme Class |
3.4.22.49 |
| Molecular Weight |
233175 |
| Protein Length |
2120 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue |
| Localization |
Cytoplasm. Nucleus. |
| Function (UniProt annotation) |
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. |
| Gene Ontology |
GO:0000070; GO:0000212; GO:0000281; GO:0003824; GO:0004197; GO:0005634; GO:0005737; GO:0005813; GO:0005829; GO:0006915; GO:0008234; GO:0040001; GO:0045143; GO:0045842; GO:0045875; GO:0051307; GO:0072686 |
