| Gene |
PLEC
|
| Protein Name |
PLEC_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1) |
| Protein Family |
Plakin or cytolinker family |
| NCBI Gene ID |
5339
|
| UniProt ID |
Q15149
|
| Enzyme Class |
- |
| Molecular Weight |
531791 |
| Protein Length |
4684 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, cytoskeleton |
| Function (UniProt annotation) |
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. |
| Gene Ontology |
GO:0003723; GO:0003779; GO:0005198; GO:0005200; GO:0005737; GO:0005829; GO:0005886; GO:0005903; GO:0005925; GO:0008307; GO:0016020; GO:0016528; GO:0030056; GO:0030506; GO:0031581; GO:0042060; GO:0042383; GO:0043034; GO:0045104; GO:0045111; GO:0045296; GO:0048471; GO:0070062 |
