| Gene |
RPS6KA2
|
| Protein Name |
KS6A2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
6196
|
| UniProt ID |
Q15349
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
83239 |
| Protein Length |
733 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. |
| Gene Ontology |
GO:0000287; GO:0004674; GO:0004711; GO:0004712; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007165; GO:0008285; GO:0016301; GO:0035556; GO:0043065; GO:0045786 |
