CaMKipedia | Result

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Sequence Viewer

Gene

RPS6KA2

Synonyms

MAPKAPK1C RSK3

Protein Name

Ribosomal protein S6 kinase alpha-2

UniProt ID

Q15349

Ensembl Gene ID

9606.ENSP00000427015

NCBI Gene ID

6196

Molecular Weight

83,239

Protein Length

733

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : N/A)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.1 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Nucleus Cytoplasm

Function

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Gene Ontology

GO:0000287; GO:0004674; GO:0004711; GO:0004712; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007165; GO:0008285; GO:0016301; GO:0035556; GO:0043065; GO:0045786

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
FOS (P01100)	Homo sapiens	S362	AAAHRKGSSSNEPSS	0.803	0.5854	-	-	-	-	11585927, 9920881	Non high throughput (11585927, 9920881)	-
CREB1 (P16220)	Homo sapiens	S133	EILSRRPSYRKILND	-	0.5055	-	-	-	-	11698596	Non high throughput (11698596)	In vivo
ATF4 (P18848)	Homo sapiens	S245	TRGSPNRSLPSPGVL	0.283	0.7629	-	-	-	-	15109498	Non high throughput (15109498)	-
DAPK1 (P53355)	Homo sapiens	S289	QALSRKASAVNMEKF	-	0.3426	-	-	-	-	16213824	Non high throughput (16213824)	-
MEF2C (Q06413)	Homo sapiens	S192	GVTHRPPSAGNTGGL	0.696	0.8623	-	-	-	-	17630987	Non high throughput (17630987)	-
Atf4 (Q06507)	Mus musculus	S251	NLPSPGGSRGSPRPK	-	0.9396	-	-	-	-	15109498	Non high throughput (15109498)	-
NFATC4 (Q14934)	Homo sapiens	S676	SNGRRKRSPTQSFRF	0.769	0.3356	-	-	-	-	15657420	Non high throughput (15657420)	-
BAD (Q92934)	Homo sapiens	S75	EIRSRHSSYPAGTED	0.509	0.8279	-	-	-	-	10558990	Non high throughput (10558990)	-
RRN3 (Q9NYV6)	Homo sapiens	S649	PVLYMQPSPL_____	0.5	0.4901	-	-	-	-	12620228	Non high throughput (12620228)	-
CDKN1B (P46527)	Homo sapiens	T198	PGLRRRQT_______	0.507	0.9519	-	-	-	-	14504289	Non high throughput (14504289)	-
RPS6KA2 (Q15349)	Homo sapiens	S218	DHDKRAYSFCGTIEY	0.78	0.1184	-	-	-	-	-	-	in-vitro
RPS6KA2 (Q15349)	Homo sapiens	T570	AGNGLLMTPCYTANF	0.752	0.1251	-	-	-	-	-	-	in-vitro

Kinase

Substrate

Interactor

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04010	MAPK signaling pathway
hsa04114	Oocyte meiosis
hsa04150	mTOR signaling pathway
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa04914	Progesterone-mediated oocyte maturation

No NCI Nature pathways found