| Gene |
MED1
|
| Protein Name |
MED1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A) |
| Protein Family |
Mediator complex subunit 1 family |
| NCBI Gene ID |
5469
|
| UniProt ID |
Q15648
|
| Enzyme Class |
- |
| Molecular Weight |
168478 |
| Protein Length |
1581 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus Note=A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. |
| Function (UniProt annotation) |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). |
| Gene Ontology |
GO:0000122; GO:0000151; GO:0000785; GO:0000902; GO:0000978; GO:0000979; GO:0000981; GO:0001047; GO:0001525; GO:0001889; GO:0001892; GO:0002088; GO:0002154; GO:0003222; GO:0003406; GO:0003682; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0006356; GO:0006367; GO:0006590; GO:0006702; GO:0007420; GO:0007595; GO:0008134; GO:0010628; GO:0010839; GO:0016020; GO:0016592; GO:0016922; GO:0019216; GO:0030216; GO:0030224; GO:0030331; GO:0030374; GO:0030375; GO:0030518; GO:0030521; GO:0031100; GO:0031490; GO:0032993; GO:0033148; GO:0033160; GO:0033601; GO:0035050; GO:0035116; GO:0035162; GO:0035257; GO:0035357; GO:0035729; GO:0035855; GO:0036033; GO:0038023; GO:0042789; GO:0042809; GO:0042974; GO:0042975; GO:0043066; GO:0045444; GO:0045618; GO:0045648; GO:0045665; GO:0045893; GO:0045944; GO:0046966; GO:0048821; GO:0048822; GO:0050693; GO:0051726; GO:0060335; GO:0060744; GO:0060745; GO:0060750; GO:0061630; GO:0070318; GO:0070371; GO:0070562; GO:0071364; GO:0071383; GO:0097067; GO:2000273; GO:2000347; GO:2001141 |
