CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	ELAVL1
Protein Name	ELAV1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	ELAV-like protein 1 (Hu-antigen R) (HuR)
Protein Family	RRM elav family
NCBI Gene ID	1994
UniProt ID	Q15717
Enzyme Class	-
Molecular Weight	36092
Protein Length	326
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:14731398). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010).
Gene Ontology	GO:0000398; GO:0003723; GO:0003725; GO:0003729; GO:0003730; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007275; GO:0010494; GO:0016020; GO:0017091; GO:0019901; GO:0035198; GO:0035925; GO:0042803; GO:0043488; GO:0045727; GO:0048255; GO:0051260; GO:0060965; GO:0070935; GO:0098794; GO:0098978; GO:1990904; GO:2000036

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK2 (O96017)	Homo sapiens	S100	VSYARPSSEVIKDAN	0.601	0.1969	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	S88	LNGLRLQSKTIKVSY	0.093	0.2988	-	-	-	-	-	-	In vitro
CHEK2 (O96017)	Homo sapiens	T118	SGLPRTMTQKDVEDM	0.405	0.3215	-	-	-	-	-	-	In vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found