| Gene |
39326
|
| Protein Name |
SEPT7_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Septin-7 (CDC10 protein homolog) |
| Protein Family |
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily |
| NCBI Gene ID |
989
|
| UniProt ID |
Q16181
|
| Enzyme Class |
- |
| Molecular Weight |
50680 |
| Protein Length |
437 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). |
| Gene Ontology |
GO:0000281; GO:0000777; GO:0000921; GO:0001725; GO:0003924; GO:0005198; GO:0005525; GO:0005634; GO:0005819; GO:0005829; GO:0005930; GO:0005940; GO:0007283; GO:0015630; GO:0016476; GO:0030154; GO:0030496; GO:0031105; GO:0032154; GO:0032160; GO:0032947; GO:0042802; GO:0045296; GO:0051291; GO:0060271; GO:0070062; GO:0097227; GO:0097730; GO:1902857 |
