CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Numb
Protein Name	NUMB_RAT
Organism	Rattus norvegicus (Rat)
Alternative name(s)	Protein numb homolog
Protein Family	N/A
NCBI Gene ID	N/A
UniProt ID	Q2LC84
Enzyme Class	-
Molecular Weight	70596
Protein Length	652
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Membrane Peripheral membrane protein.
Function (UniProt annotation)	Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage (By similarity).
Gene Ontology	GO:0008283; GO:0014069; GO:0016020; GO:0030154; GO:0045177; GO:0045664; GO:0050775; GO:0098978; GO:0099150

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Camk1 (Q63450)	Rattus norvegicus	S264	EQLARQGSFRGFPAL	N/A	N/A	TP	certain	experimental	9 \| 73 \| 55 \|	16105844	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found