CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

Camk1

Synonyms

N/A

Protein Name

Calcium/calmodulin-dependent protein kinase type 1

UniProt ID

Q63450

Ensembl Gene ID

10116.ENSRNOP00000033456

NCBI Gene ID

171503

Molecular Weight

41,638

Protein Length

374

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 1a06)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.17 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.

Function

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-516', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation (By similarity). Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-275' and 'Ser-294'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

Gene Ontology

GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0006913; GO:0007049; GO:0007165; GO:0010976; GO:0014069; GO:0032091; GO:0032880; GO:0033138; GO:0043393; GO:0045944; GO:0046827; GO:0050807; GO:0051147; GO:0051149; GO:0051835; GO:0060143; GO:0060999; GO:0071902; GO:0098978; GO:1901985

Gene Ontology

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
KRT18 (P05783)	Homo sapiens	S53	ISVSRSTSFRGGMGS	0.418	0.4541	-	certain	experimental	73 \| 72 \| 107 \| 8 \|	7523419	Non high throughput (7523419)	-
MYL9 (P24844)	Homo sapiens	S20	KRPQRATSNVFAMFD	0.877	0.5665	TP	certain	experimental	72 \| 73 \| 55 \| 8 \|	12081505	-	In vivo
Nos1 (P29476)	Rattus norvegicus	S741	LAEAVKFSAKLMGQA	-	0.1643	TP	certain	experimental	55 \| 8 \| 73 \|	15251453	-	-
Numb (Q2LC84-2)	Rattus norvegicus	S264	EQLARQGSFRGFPAL	-	-	TP	certain	experimental	9 \| 73 \| 55 \|	16105844	-	-
Numbl (Q3MUI2)	Rattus norvegicus	S304	EQLVRQGSFRGFPAL	-	0.5807	TP	certain	experimental	72 \| 31 \| 9 \| 73 \| 55 \|	16105844	-	-
Rps19 (P17074)	Rattus norvegicus	S59	WFYTRAASTARHLYL	-	0.2849	TP	certain	experimental	72 \| 62 \| 55 \| 73 \|	19200342	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found