| Gene |
E2f8
|
| Protein Name |
E2F8_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Transcription factor E2F8 (E2F-8) |
| Protein Family |
E2F/DP family |
| NCBI Gene ID |
108961
|
| UniProt ID |
Q58FA4
|
| Enzyme Class |
- |
| Molecular Weight |
93276 |
| Protein Length |
860 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. |
| Gene Ontology |
GO:0000122; GO:0000978; GO:0000981; GO:0000987; GO:0001077; GO:0001078; GO:0001890; GO:0002040; GO:0003677; GO:0003700; GO:0003714; GO:0005634; GO:0005730; GO:0005829; GO:0008134; GO:0008283; GO:0032466; GO:0032877; GO:0033301; GO:0042802; GO:0042803; GO:0043565; GO:0045944; GO:0051726; GO:0060707; GO:0060718; GO:0070365; GO:0090575 |
