| Gene |
Eif4ebp1
|
| Protein Name |
4EBP1_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) |
| Protein Family |
EIF4E-binding protein family |
| NCBI Gene ID |
13685
|
| UniProt ID |
Q60876
|
| Enzyme Class |
- |
| Molecular Weight |
12325 |
| Protein Length |
117 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
N/A |
| Function (UniProt annotation) |
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7629182). |
| Gene Ontology |
GO:0000082; GO:0002192; GO:0002931; GO:0005634; GO:0005737; GO:0005829; GO:0006446; GO:0008190; GO:0008286; GO:0030324; GO:0030371; GO:0031333; GO:0031369; GO:0031929; GO:0032991; GO:0045471; GO:0045931; GO:0045947; GO:0051721; GO:0071456; GO:0071549; GO:0098978; GO:0099524; GO:1990928 |
