| Gene |
Wee2
|
| Protein Name |
WEE2_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Wee1-like protein kinase 2 (EC 2.7.10.2) (Wee1-like protein kinase 1B) (Wee1B kinase) (mWee1B) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
381759
|
| UniProt ID |
Q66JT0
|
| Enzyme Class |
2.7.10.2 |
| Molecular Weight |
62343 |
| Protein Length |
555 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. |
| Localization |
Cytoplasm. Nucleus. Note=Localizes mainly in the nucleus. Exported from the nucleus to the cytoplasm before germinal vesicle breakdown (GVBD), allowing meiosis resumption. |
| Function (UniProt annotation) |
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. |
| Gene Ontology |
GO:0000287; GO:0004672; GO:0004713; GO:0004715; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0007093; GO:0007143; GO:0035038; GO:0045736; GO:0060631; GO:1900194 |
