CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	NHS
Protein Name	NHS_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein)
Protein Family	NHS family
NCBI Gene ID	4810
UniProt ID	Q6T4R5
Enzyme Class	-
Molecular Weight	179135
Protein Length	1651
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Isoform 1: Apical cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, tight junction. Cell junction, focal adhesion. Note=Colocalizes with the tight junction protein TJP1 in epithelial cells. Localizes to the leading edge of lamellipodia in motile cells.; Isoform 3: Cytoplasm.
Function (UniProt annotation)	May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development.
Gene Ontology	GO:0002088; GO:0005794; GO:0005923; GO:0005925; GO:0016324; GO:0016604; GO:0030027; GO:0030054; GO:0030154

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	T401	RKLRRRKTISGIPRR	0.717	0.708	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found