| Gene |
CRTC1
|
| Protein Name |
CRTC1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1) |
| Protein Family |
TORC family |
| NCBI Gene ID |
23373
|
| UniProt ID |
Q6UUV9
|
| Enzyme Class |
- |
| Molecular Weight |
67300 |
| Protein Length |
634 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. |
| Gene Ontology |
GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0005886; GO:0007613; GO:0008140; GO:0014069; GO:0016032; GO:0016604; GO:0030425; GO:0032793; GO:0043025; GO:0043153; GO:0045944; GO:0048511; GO:0051289; GO:0097009; GO:0098978; GO:0099527; GO:1900006; GO:1900273; GO:1902631 |
