CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Cpeb3
Protein Name	CPEB3_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (mCPEB-3)
Protein Family	RRM CPEB family
NCBI Gene ID	208922
UniProt ID	Q7TN99
Enzyme Class	-
Molecular Weight	78335
Protein Length	716
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (PubMed:17024188, PubMed:26074072). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (PubMed:17024188). Required for the consolidation and maintenance of hippocampal-based long term memory (PubMed:26074003). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA1 and GRIA2 and negatively regulates their translation (PubMed:17024188, PubMed:22153079). Also represses the translation of DLG4, GRIN1 GRIN2A and GRIN2B (PubMed:24155305). When activated, acts as a translational activator of GRIA1 and GRIA2 (PubMed:22153079, PubMed:26074003). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (PubMed:26074071). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (PubMed:26915043). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (PubMed:26074072). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (By similarity). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (By similarity). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (By similarity).
Gene Ontology	GO:0000122; GO:0000900; GO:0003723; GO:0003730; GO:0005634; GO:0005737; GO:0007616; GO:0008135; GO:0014069; GO:0017148; GO:0030014; GO:0030054; GO:0030425; GO:0035613; GO:0035925; GO:0043005; GO:0043022; GO:0045202; GO:0045211; GO:0045727; GO:0048167; GO:0050955; GO:0060213; GO:0060998; GO:0060999; GO:0061158; GO:0071230; GO:0097440; GO:0098794; GO:1900153; GO:1900248; GO:1900273; GO:1900365; GO:1990124; GO:2000766

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S298	SPLKKPFSSNVIAPP	N/A	0.5098	-	-	-	-	-	-	in-vivo
CAMK2A (Q9UQM7)	Homo sapiens	S420	GRRRGRSSLFPFEDA	N/A	0.2817	-	-	-	-	-	-	in-vitro and in-vivo
CAMK2A (Q9UQM7)	Homo sapiens	S299	PLKKPFSSNVIAPPK	N/A	0.5055	-	-	-	-	-	-	in-vivo
CAMK2A (Q9UQM7)	Homo sapiens	S291	PSPLNPISPLKKPFS	N/A	0.5176	-	-	-	-	-	-	in-vivo
CAMK2A (Q9UQM7)	Homo sapiens	S443	QALSSGLSSPTRCQN	N/A	0.6712	-	-	-	-	-	-	in-vivo
CAMK2A (Q9UQM7)	Homo sapiens	S419	YGRRRGRSSLFPFED	N/A	0.2783	-	-	-	-	-	-	in-vitro and in-vivo
CAMK2A (Q9UQM7)	Homo sapiens	T446	SSGLSSPTRCQNGER	N/A	0.5992	-	-	-	-	-	-	in-vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found