CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	TICRR
Protein Name	TICRR_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)
Protein Family	Treslin family
NCBI Gene ID	90381
UniProt ID	Q7Z2Z1
Enzyme Class	-
Molecular Weight	210857
Protein Length	1910
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus Note=Associates with chromatin.
Function (UniProt annotation)	Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
Gene Ontology	GO:0001731; GO:0003682; GO:0005634; GO:0005654; GO:0006260; GO:0006281; GO:0007093; GO:0010212; GO:0030174; GO:0033314

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CHEK1 (O14757)	Homo sapiens	S1045	RSVQRVHSFQQDKSD	0.886	0.8421	-	-	-	-	-	-	in-vitro
CHEK1 (O14757)	Homo sapiens	S865	NALIRHKSIAEVSQN	0.873	0.4864	-	-	-	-	-	-	in-vitro
CHEK1 (O14757)	Homo sapiens	S1894	FSRRRPISRTYTRKK	0.533	0.4541	-	-	-	-	-	-	in-vitro
CHEK1 (O14757)	Homo sapiens	T1898	RPISRTYTRKKLMGT	0.204	0.4292	-	-	-	-	-	-	in-vitro

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found