| Gene |
TLK2
|
| Protein Name |
TLK2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
11011
|
| UniProt ID |
Q86UE8
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
87661 |
| Protein Length |
772 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2. |
| Function (UniProt annotation) |
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. |
| Gene Ontology |
GO:0001672; GO:0004674; GO:0005524; GO:0005634; GO:0005882; GO:0006325; GO:0006468; GO:0006974; GO:0007049; GO:0007059; GO:0010507; GO:0018105; GO:0032435; GO:0035556; GO:0048471; GO:0071480 |
