| Gene |
BRSK2
|
| Protein Name |
BRSK2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
9024
|
| UniProt ID |
Q8IWQ3
|
| Enzyme Class |
2.7.11.1; 2.7.11.26 |
| Molecular Weight |
81633 |
| Protein Length |
736 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein.; ATP + [tau protein] = ADP + [tau protein] phosphate. |
| Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin. |
| Function (UniProt annotation) |
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. |
| Gene Ontology |
GO:0000086; GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005783; GO:0005813; GO:0006468; GO:0006887; GO:0007409; GO:0010975; GO:0018105; GO:0019901; GO:0030010; GO:0030182; GO:0031532; GO:0035556; GO:0036503; GO:0043462; GO:0048471; GO:0050321; GO:0050770; GO:0051117; GO:0051301; GO:0060590; GO:0061178; GO:0070059; GO:0090176; GO:0150034; GO:1904152; GO:2000807 |
