CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	TPH2
Protein Name	TPH2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2)
Protein Family	Biopterin-dependent aromatic amino acid hydroxylase family
NCBI Gene ID	121278
UniProt ID	Q8IWU9
Enzyme Class	1.14.16.4
Molecular Weight	56057
Protein Length	490
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
Localization	N/A
Function (UniProt annotation)	-
Gene Ontology	GO:0004510; GO:0005506; GO:0005829; GO:0007623; GO:0009072; GO:0014823; GO:0031667; GO:0042427; GO:0043005; GO:0043627; GO:0051384; GO:0051592; GO:0071285

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK2A (Q9UQM7)	Homo sapiens	S19	YWARRGFSLDSAVPE	0.5	0.4186	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found