| Gene |
NEK11
|
| Protein Name |
NEK11_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
79858
|
| UniProt ID |
Q8NG66
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
74192 |
| Protein Length |
645 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. |
| Gene Ontology |
GO:0004674; GO:0005524; GO:0005654; GO:0005730; GO:0006468; GO:0016572; GO:0031573; GO:0035556; GO:0044772; GO:0046872; GO:1901990 |
