| Gene |
BRSK1
|
| Protein Name |
BRSK1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
84446
|
| UniProt ID |
Q8TDC3
|
| Enzyme Class |
2.7.11.1; 2.7.11.26 |
| Molecular Weight |
85087 |
| Protein Length |
778 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. |
| Gene Ontology |
GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005813; GO:0006468; GO:0006974; GO:0007095; GO:0007269; GO:0007409; GO:0008021; GO:0008306; GO:0009411; GO:0010975; GO:0019901; GO:0030010; GO:0030054; GO:0030182; GO:0035556; GO:0043015; GO:0048167; GO:0048786; GO:0050321; GO:0050770; GO:0051298; GO:0090176; GO:0099504; GO:0150034; GO:2000807 |
