CaMKipedia | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Gene

CAMKK1

Synonyms

CAMKKA

Protein Name

Calcium/calmodulin-dependent protein kinase kinase 1

UniProt ID

Q8N5S9

Ensembl Gene ID

N/A

NCBI Gene ID

84254

Molecular Weight

55,735

Protein Length

505

Protein Domain

InterPro | Pfam

3D Structure
(PDB ID : 6ccf)

PDBe | PDBj | RCSB PDB
DrugPort | ModBase | SwissModel

Target by Small Molecules

chEMBL

Protein-protein Interaction Database

STRING | IntAct | MINT

Gene Expression

Gene Expression Atlas | The Human Protein Atlas

Drugs and Diseases

Open Targets | OMIM

Enzyme Class

2.7.11.17 (BRENDA)

Catalytic Site

Catalytic Site Atlas

Catalytic Activity

ATP + a protein = ADP + a phosphoprotein.

Localization

Cytoplasm Nucleus

Function

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Gene Ontology

GO:0004674; GO:0004683; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0005829; GO:0035556; GO:0045860

Substrate	Organism	PSite	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK4 (Q16566)	Homo sapiens	T200	EHQVLMKTVCGTPGY	0.785	0.0909	TP	certain	experimental	73 \| 8 \| 55 \|	8702940	-	In vitro
CAMK1D (Q8IU85)	Homo sapiens	T180	GKGDVMSTACGTPGY	0.748	0.3426	TP	certain	experimental	72 \| 73 \| 8 \| 148 \|	12935886	-	In vitro and in vivo
CAMK4 (Q16566)	Homo sapiens	S12	TVPSCSASSCSSVTA	0.5	0.1969	-	-	-	-	-	-	In vitro
CAMK4 (Q16566)	Homo sapiens	S13	VPSCSASSCSSVTAS	0.5	0.2988	-	-	-	-	-	-	In vitro
Camk4 (P13234)	Rattus norvegicus	T196	EHQVLMKTVCGTPGY	-	0.0888	-	-	-	-	15262966, 7615569, 9163534	Non high throughput (15262966, 7615569, 9163534)	-
Camk4 (P13234)	Rattus norvegicus	T200	LMKTVCGTPGYCAPE	-	0.0835	-	-	-	-	9163534	Non high throughput (9163534)	-
PRKAA1 (Q13131)	Homo sapiens	T183	SDGEFLRTSCGSPNY	0.698	0.2951	-	-	-	-	-	-	In vivo
CAMK1 (Q14012)	Homo sapiens	T177	DPGSVLSTACGTPGY	0.726	0.3286	-	-	-	-	-	-	In vitro
BRSK1 (Q8TDC3-2)	Homo sapiens	T205	VGDSLLETSCGSPHY	-	-	-	-	-	-	-	-	In vitro
Pacsin1 (Q9Z0W5)	Rattus norvegicus	T355	DRGQAYATEWSDDES	-	0.7209	-	-	-	-	-	-	in-vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system TAS \| Reactome Pathway
R-HSA-168256	Immune System TAS \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins TAS \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling TAS \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04920	Adipocytokine signaling pathway

No NCI Nature pathways found